Preimplantation Genetic Screening (PGS) is offered as a complement to a patient’s in vitro fertilisation (IVF) treatment, to improve pregnancy success rates and reduce miscarriages. PGS is testing of early stage embryos for chromosomal abnormalities.
Improving IVF success with PGS testing
Preimplantation Genetic Screening (PGS)
Preimplantation Genetic Screening (PGS) is the testing of early stage embryos for chromosomal abnormalities. Offered as a complement to a patient’s in vitro fertilisation (IVF) treatment, PGS aims to identify chromosomally normal embryos, prior to transferring embryos to a patient’s uterus. PGS is a comprehensive chromosome screening tool that has been shown to:
- Reduce time between IVF cycles, if another cycle is needed
- Increase IVF pregnancy success rates1
- Improve implantation outcomes4
- Decrease miscarriage rates3,4
A healthy pregnancy starts with a healthy embryo
Imagine DNA as a piece of string. If you coil the DNA, it would form a structure called a chromosome. Humans have 23 pairs of chromosomes (46 in total) within almost every cell in our body.
Unfortunately, human biology is not without its flaws. Several factors (such as maternal age) can affect the number of chromosomes passed into the sperm or egg. Instances can (and do) arise where missing or extra chromosomes are passed into the sperm or egg, and subsequently leads to an abnormal number of chromosomes in the embryo/foetus. Abnormal chromosome numbers are associated with either miscarriage (as they are not compatible with life) or a genetic condition (such as Down syndrome).
Preimplantation Genetic Screening (PGS) is a test that comprehensively screens all the chromosomes (Chromosome 1-22 and the sex chromosomes) in an embryo biopsy sample for any extra or missing chromosomes, and large deletions or duplications of genetic material. Selecting embryos with the correct number of chromosomes for transfer has been shown to significantly improve implantation outcomes and pregnancy success rates.2 As a result, PGS is recommended by many top fertility specialists.
Increase your chances of a healthy pregnancy with the help of PGS
Studies have shown that IVF pregnancy rates can be increased with PGS, when compared to IVF cycles that did not include PGS.
1 Yang et al. (2012). Molecular Cytogenetics 5:24 2 Liebaers et al. (2010). Human Reproduction 25:1 3 Hodes-Wertz et al. (2012). Fertility and Sterility 98:3 4 Yang et al. (2013). Molecular Cytogenetics 6:32