Having a miscarriage is a traumatic event, often leaving you with questions about what happened. More than half of first-trimester miscarriages are caused by chromosome abnormalities.1

The Prenatal Aneuploidy Screening (PAS) utilised by Genesis Genetics, is the first of its kind in South Africa, where advanced molecular technology is employed to rapidly and accurately screen products of conception (POCs) for abnormal chromosome numbers (aneuploidies), and large genetic deletions and/or duplications of chromosomal material.

Chromosomal abnormalities

Our DNA is packaged into structures called chromosomes. We normally have two copies of every chromosome. Missing or extra copies of chromosomes are referred to as aneuploidies. Having three copies of a chromosome is called a trisomy, while having only one copy of a chromosome is called a monosomy. An aneuploidy, such as a trisomy or monosomy, can result in pregnancy loss or a genetic condition.

Comprehensive chromosome screening

Chromosomal abnormalities have been associated with every chromosome. The Prenatal Aneuploidy Screening (PAS) offered by Genesis Genetics screen all the chromosomes (Chromosomes 1-22), including the sex chromosomes (X & Y).

  • Coverage of all chromosomes in the genome
  • Detection of additional clinically relevant genetic abnormalities when compared to conventional karyotyping
  • Test failure rates of <1%
  • Pick-up rates of approximately 50%
  • High resolution
  • No need for cell culturing
  • Faster turnaround time

1 Wapner et al. (2012) NEJM 367 (23): 2175-2184. 2 Jeve et all. J Hum Reprod Sci. 2014 Jul-Sep; 7(3): 159–169.