The TriScreen Non-Invasive Prenatal Test (NIPT) is an accurate, early prenatal screen for Down syndrome and other common chromosomal conditions. The test only involves a simple blood draw from the pregnant mother and can be undertaken from 10 weeks’ gestational age.

Did you know that your baby’s DNA circulates in your bloodstream while you’re pregnant

During pregnancy, some of your baby’s DNA enters your bloodstream. A simple blood test early in your pregnancy can analyse this DNA, screening for common chromosomal conditions such as Down syndrome.

Imagine DNA as a piece of string. If you coil the DNA, it would form a structure called a chromosome. Humans have 23 pairs of chromosomes (46 in total) within almost every cell in our body. One chromosome of each pair comes from our mother, and the other from our father. The first chromosome pairs are labelled 1-22. The last pair of these chromosomes are the sex chromosomes, which determine sex. Females usually have two X chromosomes, and males have an X and a Y chromosome. A change in the number of chromosomes can lead to a change in development. Having an extra copy of a chromosome is called a trisomy (three copies), while missing a copy of a chromosome (having only one copy) is called a monosomy. A trisomy or monosomy can result in a genetic condition, such as Down syndrome. Individuals with Down syndrome have 3 copies of chromosome 21 (Trisomy 21).


TriScreen – Non-Invasive Prenatal Testing (NIPT)

The TriScreen Non-Invasive Prenatal Test (NIPT) is a simple blood test that analyses the DNA of an unborn baby, found in the mothers’ blood, to detect certain chromosomal conditions in a pregnancy. The TriScreen NIPT can be done from as early as 10 weeks and is more accurate than an ultrasound and the maternal blood test to detect chromosomal conditions, providing a greater sense of comfort.

TriScreen screens your pregnancy for the following chromosomal conditions:

  • Down syndrome (Trisomy 21)
  • Edwards syndrome (Trisomy 18)
  • Patau syndrome (Trisomy 13)
  • Sex chromosome conditions including Turner syndrome (Monosomy X) and Klinefelter
    syndrome (XXY)
  • Option of all chromosome testing (as advised by your Healthcare Provider).

How to order TriScreen NIPT

To have your bloods drawn for TriScreen NIPT:
Send the completed TriScreen NIPT Test Requisition form from your doctor to or fax to 086 567 3957 and we will send a nurse to you for the blood draw


Visit the Next Biosciences +1 Hub in Sandton:

  • Quick and Convenient
  • No appointment required
  • Open Monday, Wednesday and Thursday 7:30am-16:00pm and Tuesday and Friday 7:00am-15:30pm

Please call 011 697 2900 for more information on any of the above options.

Genesis Genetics supports responsible genetic testing and may refer you to a genetic counsellor before you undertake NIPT.

For more information on Non-Invasive Prenatal Testing (NIPT), watch this short video:

  • Singleton pregnancies
  • Twin pregnancies
  • Donor pregnancies
  • IVF pregnancies (from 8 weeks post-implantation)
  • Surrogate pregnancies
Singleton pregnancies:
  1. Chromosomes 21, 18, 13 and sex chromosome anomalies
  2. Chromosomes 21, 18, 13, sex chromosome anomalies and microdeletions*
  3. All chromosomes
  4. All chromosomes and microdeletions*
Twin pregnancies:
  1. Chromosomes 21, 18, 13 and presence/absence of Y chromosome (no anomalies tested of sex chromosomes)
Please note for options 2, 3 and 4 there is an extra cost and longer turnaround time.

*Microdeletions includes the following syndromes: 22q11 deletion (Di George); 15q11 deletion (Angelman/Prader-Willi); 1p36 deletion; 4p- (Wolf-Hirschhorn); 5p- (Cri-du-chat)
TriScreen NIPT uses a sample of the mother’s blood, which is sent to our Genesis Genetics laboratory in London, United Kingdom for testing.
The results will be sent to your Ordering Obstetrician/Gynaecologist within 7-10 working days from the date of blood draw.
Yes, unlike an amniocentesis or chorionic villus sampling (CVS), NIPT is non-invasive to your baby, as it uses a simple blood sample taken from your arm while you are pregnant. NIPT does not carry the risk of complications that invasive procedures have, such as miscarriage.
NIPT is usually offered to pregnant women identified by their doctor to have a chance of a foetus with a missing or extra chromosome. NIPT offers a new choice to women to have accurate information about their pregnancy, from a simple blood draw, with little or no risk to their pregnancy.
This simple test only requires a single blood draw from your arm, and can be done from as early as 10 weeks of pregnancy. The TriScreen NIPT can be performed on singleton and twin pregnancies, as well as donor and surrogate pregnancies.
The TriScreen NIPT is not affected by body mass index (BMI) or ethnic background.
Yes, TriScreen can test pregnancies conceived via ART, such as IVF.
No, apart from a blood sample from a pregnant mother, the TriScreen NIPT does not require any additional genetic information from any other person.
No test can guarantee that a baby will not have any medical issues. It does not test for all genetic and non-genetic problems that may be present in a baby. Genetic counselling before and after testing is recommended.