The TriScreen Non-Invasive Prenatal Test (NIPT) is an accurate, early prenatal screen for Down syndrome and other common chromosomal conditions. The test only involves a simple blood draw from the pregnant mother and can be undertaken from 10 weeks’ gestational age.
Did you know that your baby’s DNA circulates in your bloodstream while you’re pregnant
During pregnancy, some of your baby’s DNA enters your bloodstream. A simple blood test early in your pregnancy can analyse this DNA, screening for common chromosomal conditions such as Down syndrome.
Imagine DNA as a piece of string. If you coil the DNA, it would form a structure called a chromosome. Humans have 23 pairs of chromosomes (46 in total) within almost every cell in our body. One chromosome of each pair comes from our mother, and the other from our father. The first chromosome pairs are labelled 1-22. The last pair of these chromosomes are the sex chromosomes, which determine sex. Females usually have two X chromosomes, and males have an X and a Y chromosome. A change in the number of chromosomes can lead to a change in development. Having an extra copy of a chromosome is called a trisomy (three copies), while missing a copy of a chromosome (having only one copy) is called a monosomy. A trisomy or monosomy can result in a genetic condition, such as Down syndrome. Individuals with Down syndrome have 3 copies of chromosome 21 (Trisomy 21).
TriScreen – Non-Invasive Prenatal Testing (NIPT)
The TriScreen Non-Invasive Prenatal Test (NIPT) is a simple blood test that analyses the DNA of an unborn baby, found in the mothers’ blood, to detect certain chromosomal conditions in a pregnancy. The TriScreen NIPT can be done from as early as 10 weeks and is more accurate than an ultrasound and the maternal blood test to detect chromosomal conditions, providing a greater sense of comfort.
TriScreen screens your pregnancy for the following chromosomal conditions:
- Down syndrome (Trisomy 21)
- Edwards syndrome (Trisomy 18)
- Patau syndrome (Trisomy 13)
- Sex chromosome conditions including Turner syndrome (Monosomy X) and Klinefelter
How to order TriScreen NIPT
To have your bloods drawn for TriScreen NIPT:
Send the completed TriScreen NIPT Test Requisition form from your doctor to firstname.lastname@example.org or fax to 086 567 3957 and we will send a nurse to you for the blood draw
Visit the Next Biosciences +1 Hub in Sandton:
- Quick and Convenient
- No appointment required
- Open Monday, Wednesday and Thursday 7:30am-16:00pm and Tuesday and Friday 7:00am-15:30pm
Please call 011 697 2900 for more information on any of the above options.
Genesis Genetics supports responsible genetic testing and may refer you to a genetic counsellor before you undertake NIPT.
For more information on Non-Invasive Prenatal Testing (NIPT), watch this short video:
- Singleton pregnancies: for Chromosomes 21, 18 and 13 and sex chromosome anomalies
- Twin pregnancies: for Chromosomes 21, 18 and 13, and the presence of a Y chromosome, which can provide insight to the foetal sex
- Donor pregnancies
- IVF pregnancies
- Surrogate pregnancies
- With an extended panel option for singleton pregnancies which includes the following syndromes: 22q11 deletion (DiGeorge); 15q11 deletion (Angelman/Prader-Willi); 1q36 deletion; 4p- (Wolf-Hirschhorn); 5p- (Cri-du-chat); Trisomies 9 and 16. If recommended by an Obstetrician/Gynaecologist.
|Chromosome||Observed Sensitivity||Observed Specificity|
|21 (Down syndrome)||99.14%||99.94%|
|18 (Edwards syndrome)||97.4%||99.9%|
|13 (Patau syndrome)||98.15%||99.95%|
|Monosomy X (Turner syndrome)||95%||99%|